Polymalate (PMA) biosynthesis and its molecular regulation in Aureobasidium spp.

It has been well documented that different strains of Aureobasidium spp. can synthesize and secrete over 30.0 g/L of polymalate (PMA) and the produced PMA has many potential applications in biomaterial, medical and food industries. The substrates for PMA biosynthesis include glucose, xylose, fructose, sucrose and glucose or fructose or xylose or sucrose-containing natural materials from industrial and agricultural wastes. Malate, the only monomer for PMA biosynthesis mainly comes from TCA cycle, cytosolic reduction TCA pathway and the glyoxylate cycle. The PMA synthetase (a NRPS) containing A like domain, T domain and C like domain is responsible for polymerization of malate into PMA molecules by formation of ester bonds between malates. PMA biosynthesis is regulated by the transcriptional activator Crz1 from Ca2+ signaling pathway, the GATA-type transcription factor Gat1 from nitrogen catabolite repression and the GATA-type transcription factor NsdD. Copyright © 2021 Elsevier B.V. All rights reserved.

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Cong-Yan Qi, Shu-Lei Jia, Guang-Lei Liu, Lu Chen, Xin Wei, Zhong Hu, Zhen-Ming Chi, Zhe Chi. Polymalate (PMA) biosynthesis and its molecular regulation in Aureobasidium spp. International journal of biological macromolecules. 2021 Mar 31;174:512-518

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PMID: 33548308

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