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The CD300 molecule family is a type I transmembrane glycoprotein expressed on cell membrane of human and other mammals, and of its eight members, only CD300a and CD300f are classified as inhibitory receptors. CD300a and CD300f play an important role in regulating the function of leukocytes, such as activation, proliferation, differentiation, migration and immunity function. They are considered as potential targets for studying the development and progression of inflammation, infection and other diseases. Here, we review the expression and regulatory mechanisms of CD300a and CD300f on leukocytes, as well as their effects on relevant diseases. Copyright © 2021 Elsevier B.V. All rights reserved.


Yue Cao, Tianrang Ao, Xiaohong Wang, Wumei Wei, Jun Fan, Xiaohong Tian. CD300a and CD300f molecules regulate the function of leukocytes. International immunopharmacology. 2021 Apr;93:107373

PMID: 33548578

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