Spontaneous remission of relapsed skin lesions of ALK-positive anaplastic large cell lymphoma after autologous stem cell transplantation].

Rie Yamazaki, Yuya Koda, Ryohei Abe, Masatoshi Sakurai, Taku Kikuchi, Jun Kato, Takeshi Ouchi, Shuji Mikami, Takehiko Mori

[Rinsho ketsueki] The Japanese journal of clinical hematology 2021

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A 44-year-old woman was diagnosed with anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL) with clinical stage IVA (nodal and bladder involvement). Complete response (CR) was achieved after the CHOP chemotherapy; however, 12 months after the last course of chemotherapy, ALCL relapsed in the form of skin lesions without nodal involvement. After achieving a second CR with chemotherapy, autologous stem cell transplantation was performed. Two months after transplantation, the disease again relapsed as multiple skin lesions. Electron beam irradiation was performed; however, other skin lesions appeared thereafter and spontaneously disappeared. At present, 3.4 years after the transplantation, the patient is free from disease. ALK-positive ALCL relapsing as skin lesions may behave differently from the nodal relapse. An accumulation of cases is required to elucidate ALCL characteristics relapsing as skin lesions.

Citation

Rie Yamazaki, Yuya Koda, Ryohei Abe, Masatoshi Sakurai, Taku Kikuchi, Jun Kato, Takeshi Ouchi, Shuji Mikami, Takehiko Mori. Spontaneous remission of relapsed skin lesions of ALK-positive anaplastic large cell lymphoma after autologous stem cell transplantation]. [Rinsho ketsueki] The Japanese journal of clinical hematology. 2021;62(1):25-29