Disseminated aspergillosis due to Aspergillus udagawae during immunosuppressive treatment for myelodysplastic syndrome].

[Rinsho ketsueki] The Japanese journal of clinical hematology 2021

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An 80 year old male who had received immunosuppressive therapy for myelodysplastic syndrome presented with fever, fatigue, and elevated serum Aspergillus antigen. Computed tomography revealed infiltrative shadows in the left lower lung and subcutaneous nodules. A polymerase chain reaction assay from lung and subcutaneous nodule samples identified the presence Aspergillus udagawae. A. udagawae is a cryptic species that shares similar morphological characteristics with A. fumigatus but genetically differs from the latter in its susceptibility to antifungal drugs. When immunosuppressed patients with hematological malignancies develop disseminated aspergillosis, biopsy and fungal tests are crucial to identify the causative fungus, including cryptic species, for deciding the appropriate therapeutic intervention.

Citation

Ayumi Kuzume, Junichiro Yuda, Masahiro Abe, Takuya Yamaguchi, Mari Hisano, Nobuhiko Yamauchi, Hirotaka Nakamura, Akihito Nagata, Chi Song-Gi, Eibai Kaku, Shigeki Nakamura, Yoshitsugu Miyazaki, Yosuke Minami. Disseminated aspergillosis due to Aspergillus udagawae during immunosuppressive treatment for myelodysplastic syndrome]. [Rinsho ketsueki] The Japanese journal of clinical hematology. 2021;62(1):51-54