sym-2 loss-of-function causes glutamatergic neurodegeneration after oxidative stress.

Although some RNA-binding proteins are known to contribute to neurodegeneration, the genetic interaction between the genes encoding these proteins is unclear. Here, we examine the interaction between sym-2, the gene encoding an ortholog of hnRNPF and hnRNPH, and hrpa-1, the ortholog of of the gene encoding hnRNPA2, which when mutated causes multisystem proteinopathy. We find that after 22 hours, but not 4 hours, of paraquat-induced oxidative stress, sym-2(mn617) has a mild glutamatergic neurodegeneration phenotype. Interestingly, this defect is rescued by expression of chimeric WT hrpa-1, but not mutant. Thus, we identify a curious genetic interaction between sym-2 and hrpa-1. Copyright: © 2021 by the authors.

Citation

Veronica H Ryan, Anne C Hart. sym-2 loss-of-function causes glutamatergic neurodegeneration after oxidative stress. microPublication biology. 2021 Feb 03;2021

PMID: 33554054

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