Transcriptional and Metabolic Control of Memory B Cells and Plasma Cells.

Tyler J Ripperger, Deepta Bhattacharya

Annual review of immunology 2021 Apr 26

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For many infections and almost all vaccines, neutralizing-antibody-mediated immunity is the primary basis and best functional correlate of immunological protection. Durable long-term humoral immunity is mediated by antibodies secreted by plasma cells that preexist subsequent exposures and by memory B cells that rapidly respond to infections once they have occurred. In the midst of the current pandemic of coronavirus disease 2019, it is important to define our current understanding of the unique roles of memory B cells and plasma cells in immunity and the factors that control the formation and persistence of these cell types. This fundamental knowledge is the basis to interpret findings from natural infections and vaccines. Here, we review transcriptional and metabolic programs that promote and support B cell fates and functions, suggesting points at which these pathways do and do not intersect.

Citation

Tyler J Ripperger, Deepta Bhattacharya. Transcriptional and Metabolic Control of Memory B Cells and Plasma Cells. Annual review of immunology. 2021 Apr 26;39:345-368