Noncanonical Functions of the Polycomb Group Protein EZH2 in Breast Cancer.

Talha Anwar, Maria E Gonzalez, Celina G Kleer

The American journal of pathology 2021 May

filter terms:

Enhancer of Zeste Homologue 2 (EZH2) is the catalytic subunit of the polycomb repressive complex 2 (PRC2) that is critical for determining cell identity. An epigenetic writer, EZH2 has a well-defined role in transcriptional repression by depositing trimethyl marks on lysine 27 of histone H3. However, there is mounting evidence that histone methyltransferases like EZH2 exert histone methyltransferase-independent functions. The relevance of these functions to breast cancer progression and their regulatory mechanisms are only beginning to become understood. Here, we review the current understanding of EZH2 H3K27me3-independent, noncanonical, functions and their regulation in breast cancer. Copyright © 2021 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

Citation

Talha Anwar, Maria E Gonzalez, Celina G Kleer. Noncanonical Functions of the Polycomb Group Protein EZH2 in Breast Cancer. The American journal of pathology. 2021 May;191(5):774-783