A case of early syphilitic hepatitis with jaundice cured by high-dose amoxicillin and probenecid].

Wakano Kobayashi, Makiko Matsumura, Hiroko Kuba, Eigo Kojima

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2021

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A 44-year-old man was admitted because of general malaise, jaundice, and epigastric pain. The patient had no significant medical history. However, the patient visited a brothel 3 months ago and noticed initial induration on his penis 2 months ago. Physical examination revealed swelling surface lymph nodes in the inguinals. Laboratory examination showed moderate hepatic disorder and jaundice. Hepatitis virus markers and various types of autoantibodies were negative, but serological test for syphilis was positive. The symptoms and abnormal data improved immediately after the patient was treated with amoxicillin (3000mg/day) and probenecid (750mg/day). Thus, a diagnosis of early syphilitic hepatitis was established. In addition, syphilis is not just a genital disease. This disease should be thought of in a patient with liver dysfunction, especially among people of high sexual activity.

Citation

Wakano Kobayashi, Makiko Matsumura, Hiroko Kuba, Eigo Kojima. A case of early syphilitic hepatitis with jaundice cured by high-dose amoxicillin and probenecid]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology. 2021;118(2):161-167