A case of Anti-LGi1 antibody positive autoimmune epilepsy following deep brain stimulator implantation for essential tremor.

Reuben Beer, Alex Lehn, Stefan Blum

Journal of neuroimmunology 2021 Apr 15

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We describe a 59-year-old male who developed faciobrachial dystonic seizures and serum Anti-LGi1 antibody positivity 5 weeks after subthalamic deep brain stimulation (DBS) implantation for essential tremor. Brain MRI prior to implantation was normal. Electroencephalogram was normal. A lung lesion with low PET avidity was identified and biopsied; histology was non-diagnostic. Treatment response to immunoglobulin was observed. Seizures after DBS implantation are rare, and to our knowledge not described in association with anti-LGi1 antibodies. Copyright © 2021 Elsevier B.V. All rights reserved.

Citation

Reuben Beer, Alex Lehn, Stefan Blum. A case of Anti-LGi1 antibody positive autoimmune epilepsy following deep brain stimulator implantation for essential tremor. Journal of neuroimmunology. 2021 Apr 15;353:577503