Plasminogen Receptors and Fibrinolysis.

Lindsey A Miles, Lina Ny, Malgorzata Wilczynska, Yue Shen, Tor Ny, Robert J Parmer

International journal of molecular sciences 2021 Feb 08

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The ability of cells to promote plasminogen activation on their surfaces is now well recognized, and several distinct cell surface proteins have been demonstrated to function as plasminogen receptors. Here, we review studies demonstrating that plasminogen bound to cells, in addition to plasminogen directly bound to fibrin, plays a major role in regulating fibrin surveillance. We focus on the ability of specific plasminogen receptors on eukaryotic cells to promote fibrinolysis in the in vivo setting by reviewing data obtained predominantly in murine models. Roles for distinct plasminogen receptors in fibrin surveillance in intravascular fibrinolysis, immune cell recruitment in the inflammatory response, wound healing, and lactational development are discussed.

Citation

Lindsey A Miles, Lina Ny, Malgorzata Wilczynska, Yue Shen, Tor Ny, Robert J Parmer. Plasminogen Receptors and Fibrinolysis. International journal of molecular sciences. 2021 Feb 08;22(4)