Nano-engineering of ketorolac tromethamine platforms for ocular treatment of inflammatory disorders.

Mireia Mallandrich, Ana C Calpena, Beatriz Clares, Alexander Parra, María L García, José L Soriano, Francisco Fernández-Campos

Nanomedicine (London, England) 2021 Feb

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Aim: The development and optimization of Ketorolac tromethamine-loaded polylactic-co-glycolic acid nanoparticles (KT-NPs) for the treatment of inflammatory processes of the eye. Materials & methods: KT-NPs were developed by factorial design and characterized by assessing their physicochemical properties. Biopharmaceutical behavior studies, ocular tolerance, anti-inflammatory efficacy and bioavailability tests were performed on pigs. Results: Optimized KT-NPs of 112 nm, narrow distribution with encapsulation efficiency near 100% were obtained. KT release followed the Weibull model and there was significantly greater retention in the cornea and sclera than in the commercial reference. KT-NPs showed no signs of ocular irritancy and similar anti-inflammatory efficacy to the commercial reference. Conclusion: KT-NPs were a suitable alternative for the treatment of inflammatory disorders of the anterior and posterior segments of the eye as an alternative to conventional topical formulations.

Citation

Mireia Mallandrich, Ana C Calpena, Beatriz Clares, Alexander Parra, María L García, José L Soriano, Francisco Fernández-Campos. Nano-engineering of ketorolac tromethamine platforms for ocular treatment of inflammatory disorders. Nanomedicine (London, England). 2021 Feb;16(5):401-414