The Association between Serum Heme Oxygenase-1 Levels and Coronary SYNTAX Score.

The relationship between heme oxygenase-1 (HO-1) levels and atherosclerosis was investigated in multiple studies. The aim of this study was to establish the relationship between HO-1 levels and coronary SYNergy between percutaneous coronary intervention with TAXus and Cardiac Surgery (SYNTAX) score in patients with stable coronary artery disease (CAD). Patients who had been planned to undergo invasive coronary angiography due to a suspected CAD, between the dates of September and December 2019, were included in the study. Serum HO-1 levels were measured from peripheral venous blood. The SYNTAX score was calculated using standard coronary angiography images. Regression analysis was performed to establish the relationship between HO-1 levels and the SYNTAX score. In total, 137 patients were included. The median age was 63 years (IQR: 15), and most of the patients were male (75.2%). The median HO-1 level was 1.44 (IQR: 0.88) ng/mL, and the median SYNTAX score was 6 (IQR: 13). Regression analysis showed that HO-1 is the single most important variable associated with the SYNTAX score (HO-1 levels from 1.01 to 1.87 ng/mL, OR: 6.77, 95% confidence interval 5.18-8.36, p < 0.0001). In this study, serum HO-1 levels were significantly associated with the coronary SYNTAX score. © 2021 S. Karger AG, Basel.

Citation

Mustafa Aytek Simsek, Betül Korkmaz, Adnan Ezici, Ayca Turer Cabbar, Emre Aslanger, Flora Ozkalayci, Can Yucel Karabay, Muzaffer Degertekin. The Association between Serum Heme Oxygenase-1 Levels and Coronary SYNTAX Score. Cardiology. 2021;146(3):288-294

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PMID: 33588423

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