Correlation Engine 2.0
Clear Search sequence regions

  • apoptosis (2)
  • cancer (6)
  • flavonoid (1)
  • heterografts (1)
  • hispidulin (8)
  • humans (1)
  • metastasis (1)
  • PPAR gamma (2)
  • prostate (5)
  • xenograft (2)
  • Sizes of these terms reflect their relevance to your search.

    Prostate cancer (PCa) is one of the important factors of cancer deaths especially in the western countries. Hispidulin (4',5,7-trihydroxy-6-methoxyflavone) is a phenolic flavonoid compound proved to possess anticancer properties, but its effects on PCa are left to be released. The aims of this study were to investigate the effects and the relative mechanisms of Hispidulin on PCa development. Hispidulin administration inhibited proliferation, invasion, and migration, while accelerated apoptosis in Du145 and VCaP cells, which was accompanied by PPARγ activation and autophagy enhancement. The beneficial effects of Hispidulin could be diminished by PPARγ inhibition. Besides, Hispidulin administration suppressed PCa tumorigenicity in Xenograft models, indicating the anticancer properties in vivo. Therefore, our work revealed that the anticancer properties of Hispidulin might be conferred by its activation on PPARγ and autophagy. © The Author(s) 2020. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry.


    Yuanyuan Wang, Shanqi Guo, Yingjie Jia, Xiaoyu Yu, Ruiyu Mou, Xiaojiang Li. Hispidulin inhibits proliferation, migration, and invasion by promoting autophagy via regulation of PPARγ activation in prostate cancer cells and xenograft models. Bioscience, biotechnology, and biochemistry. 2021 Mar 24;85(4):786-797

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 33590833

    View Full Text