In vitro selection of an RNA aptamer yields an interleukin-6/interleukin-6 receptor interaction inhibitor.

Takehiro Ando, Mizuki Yamamoto, Yukio Takamori, Keita Tsukamoto, Daisuke Fuji, Takashi Kawakami

Bioscience, biotechnology, and biochemistry 2021 Apr 24

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Interleukin-6 (IL-6) binds to the IL-6 receptor (IL-6R) subunit, related to autoimmune diseases and cytokine storm in COVID-19. In this study, we performed systematic evolution of ligands by exponential enrichment and identified a novel RNA aptamer. This RNA aptamer not only bound to IL-6R with a dissociation constant of 200 n m, but also inhibited the interaction of IL-6R with IL-6. © The Author(s) 2021. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry.

Citation

Takehiro Ando, Mizuki Yamamoto, Yukio Takamori, Keita Tsukamoto, Daisuke Fuji, Takashi Kawakami. In vitro selection of an RNA aptamer yields an interleukin-6/interleukin-6 receptor interaction inhibitor. Bioscience, biotechnology, and biochemistry. 2021 Apr 24;85(5):1170-1174