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    Herein is a report on the molecular exchange occurring between multilateral symbiosis partners-a tit-for-tat exchange that led to the characterization of two new metabolites, conocandin B (fungal-derived) and dentigerumycin F (bacterial-derived). The structures were determined by NMR, mass spectrometry, genomic analysis, and chemical derivatizations. Conocandin B exhibits antimicrobial activity against both the bacterial symbionts of fungus-growing ant and human pathogenic strains by selectively inhibiting FabH, thus disrupting fatty acid biosynthesis.

    Citation

    Munhyung Bae, Emily Mevers, Gleb Pishchany, Sarah G Whaley, Charles O Rock, David R Andes, Cameron R Currie, Monica T Pupo, Jon Clardy. Chemical Exchanges between Multilateral Symbionts. Organic letters. 2021 Mar 05;23(5):1648-1652

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    PMID: 33591189

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