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General paralysis of insane is a form of neurosyphilis which brings parenchymatous changes in the central nervous system. Its manifestations include a variety of neuropsychiatric symptoms ranging from cognitive impairment to overt psychosis. Clinicians face difficulties in proper diagnosis as variety of symptoms changes from one form to other within a short period of time. Rarity of the disease at this modern era of penicillin is also another factor in timely diagnosis and management of such cases. Here we present a case of general paralysis of insane who presented with variety of neuropsychiatric symptoms and have had great difficulties to reach into the diagnosis.

Citation

S Upadhyaya, S B Pant, S Dhungana, P Tulachan, M Chapagai, S P Ojha. Neuropsychiatric manifestations in General Paralysis of Insane (GPI). Kathmandu University medical journal (KUMJ). 2020 Apr-Jun;18(70):207-209

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PMID: 33594034

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