Bruch's membrane opening-minimum rim width: An alternative OCT biomarker study for multiple sclerosis.

Kemal Turgay Özbilen, Tuncay Gündüz, Selva Nur Çukurova Kartal, Ali Ceyhun Gedik, Mefküre Eraksoy, Murat Kürtüncü

European journal of ophthalmology 2021 Jul

filter terms:

Bruch's membrane opening-minimum rim width (BMO-MRW) and RNFL measured using anatomic positioning system (APS-RNFL) are novel OCT methods and remained unexplored in MS patients.To investigate the novel parameters of spectral-domain OCT as an alternative biomarker in patients with multiple sclerosis (MS). Retrospective cohort study; participants consisted of relapsing-remitting MS (RRMS) patients and healthy controls (HC). Eyes were classified according to the presence of MS and previous optic neuritis (ON). Measurements of standard peripapillary RNFL (S-RNFL), BMO-MRW, and APS-RNFL were performed. A total of 244 eyes of 122 participants (MS-patients: 63, HC: 59) were included in the study. Fifty-one eyes had a history of previous ON. In almost all measured parameters, neuroretinal rim thicknesses were observed the thinnest in eyes with ON history between all subgroups. S-RNFL and APS-RNFL techniques showed the difference in neuroretinal rim thickness in all three subjects (ON+, ON-, and HC). However, BMO-MRW, on the other hand, could not distinguish between ON(-) patients and HC. The relationship between OCT parameters and EDSS were observed only in eyes with an ON history in all three techniques. A meaningful model with 78% accuracy was obtained by using only the OCT parameters as risk factors. In the ROC analysis, no parameters were found to have acceptable high sensitivity and specificity. BMO-MRW was statistically weaker in every aspect than other RNFL techniques. The novel APS-RNFL technique appears to be a bit more reliable alternative to S-RNFL technique to support therapeutic decision-making in MS. BMO-MRW has not been found as a successful alternative to S-RNFL.

Citation

Kemal Turgay Özbilen, Tuncay Gündüz, Selva Nur Çukurova Kartal, Ali Ceyhun Gedik, Mefküre Eraksoy, Murat Kürtüncü. Bruch's membrane opening-minimum rim width: An alternative OCT biomarker study for multiple sclerosis. European journal of ophthalmology. 2021 Jul;31(4):2141-2149