Palladium-Catalyzed Dehydrogenative Fluoroalkoxylation of Benzaldehydes.

A direct and efficient palladium-catalyzed oxidative dehydrogenative fluoroalkoxylation of benzaldehydes is reported here for the first time. The method features mild reaction conditions, good tolerance of functional groups, and a broad substrate scope. The protocol employs the transient directing group strategy, thereby avoiding the additional installation and removal of directing groups, endowing the method with great advantages of atom and step economy. The approach should find broad applications in drug synthesis and discovery processes.

Citation

Long Jin, Xing-Long Zhang, Rui-Li Guo, Meng-Yue Wang, Ya-Ru Gao, Yong-Qiang Wang. Palladium-Catalyzed Dehydrogenative Fluoroalkoxylation of Benzaldehydes. Organic letters. 2021 Mar 05;23(5):1921-1927

PMID: 33606544

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