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In this issue of Molecular Cell, Chen et al. (2020) report the structural transition during DNA-dependent activation of DNA-PK, shedding light on the mechanism by which kinase inhibitors and auto-phosphorylation-deficient DNA-PKcs compromise non-homologous end-joining (Chen et al., 2020). Copyright © 2021 Elsevier Inc. All rights reserved.
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Shan Zha, Zhengping Shao, Yimeng Zhu. The plié by DNA-PK: dancing on DNA. Molecular cell. 2021 Feb 18;81(4):644-646
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PMID: 33606972
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