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Blocking the Enablers: Selective Inhibition of CDK9 Reins in an Unchecked Master Regulator.

Aseem Z Ansari

Cell chemical biology 2021 Feb 18


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    In their quest to disable androgen receptor variants that drive castration-resistant prostate cancer, Richters et al. (2020) have hit upon a selective inhibitor of a transcriptional kinase that enables full-length mRNA synthesis. Drugging this essential kinase curbs tumor growth, thus making it an attractive focal target for transcription therapy. Copyright © 2021 Elsevier Ltd. All rights reserved.

    Citation

    Aseem Z Ansari. Blocking the Enablers: Selective Inhibition of CDK9 Reins in an Unchecked Master Regulator. Cell chemical biology. 2021 Feb 18;28(2):113-115

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    PMID: 33607002

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