Salivary CCL20 Level as a Biomarker for Oral Squamous Cell Carcinoma.

Sei Ueda, Mitsuo Goto, Kengo Hashimoto, Shogo Hasegawa, Masahiko Imazawa, Marico Takahashi, Ichiro Oh-Iwa, Kazuo Shimozato, Toru Nagao, Shuji Nomoto

Cancer genomics & proteomics 2021 Mar-Apr

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This study investigated the utility of C-C motif chemokine ligand 20 (CCL20) expression in saliva as a biomarker for oral squamous cell carcinoma (OSCC) and also examined the associated microbiome. The study group included patients with OSCC or oral potentially malignant disorder (OPMD), and healthy volunteers (HVs). microarray and qRT-PCR were used to compare salivary CCL20 expression levels among groups. Data on CCL20 levels in oral cancer tissues and normal tissues were retrieved from a public database and examined. Furthermore, next-generation sequencing was used to investigate the salivary microbiome. A significant increase in the expression level of CCL20 was observed in both OSCC tissues and saliva from patients with oral cancer. Fusobacterium was identified as the predominant bacteria in OSCC and correlated with CCL20 expression level. OSCC screening based on salivary CCL20 expression enabled successful differentiation between patients with OSCC and HVs. CCL20 expression may be a useful biomarker for OSCC. Copyright© 2021, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Citation

Sei Ueda, Mitsuo Goto, Kengo Hashimoto, Shogo Hasegawa, Masahiko Imazawa, Marico Takahashi, Ichiro Oh-Iwa, Kazuo Shimozato, Toru Nagao, Shuji Nomoto. Salivary CCL20 Level as a Biomarker for Oral Squamous Cell Carcinoma. Cancer genomics & proteomics. 2021 Mar-Apr;18(2):103-112