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Locoregional recurrence occurs in 10%-30% of non-small cell lung cancer (NSCLC) after treatment with definitive (chemo)radiotherapy. Re-irradiation is the main curative-intent treatment option for these patients; however, it represents a therapeutic challenge for thoracic radiation oncologists. Re-irradiation practices are variable worldwide with lack of agreement on the optimal dose or the cumulative maximum dose acceptable for critical organs. The role of re-irradiation in NSCLC is also not clearly defined in the era of immunotherapy. In this review, we will present published and on-going re-irradiation studies for recurrent NSCLC. We will appraise available evidence for critical organ dose constraints and provide a framework for future therapeutic approaches and trials. Copyright © 2020 Elsevier Inc. All rights reserved.


Benjamin Hunter, Cathryn Crockett, Corrinne Faivre-Finn, Crispin Hiley, Ahmed Salem. Re-Irradiation of Recurrent Non-Small Cell Lung Cancer. Seminars in radiation oncology. 2021 Apr;31(2):124-132

PMID: 33610269

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