Treatment of infantile fibrosarcoma associated to an abdominal aortic aneurysm with larotrectinib: a case report.

Infantile fibrosarcoma (IFS) is a rare pediatric tumor which often presents the ETV6-NTRK3 gene fusion. NTRK3 encodes the neurotrophin-3 growth factor receptor tyrosine kinase, a druggable therapeutic target. Selective tropomyosin receptor kinase (TRK) inhibitors, such as larotrectinib, have shown efficacy and safety in the treatment of IFS. We report a case of an abdominal IFS diagnosed in a newborn associated with an aortic aneurysm that was successfully treated with larotrectinib without relevant adverse effects.

Citation

María Dolores Corral Sánchez, Víctor Galán Gómez, Ana Sastre Urgelles, Diego Plaza López de Sabando, Pedro Rubio Aparicio, Leopoldo Martínez Martínez, Eduardo Alonso Gamarra, José Juan Pozo Kreilinger, Rita María Regojo Zapata, Juan Carlos López Gutiérrez, Eugenia Antolín Alvarado, Felipe Gómez Martín, Ana María Sánchez Torres, Elena Marín Manzano, Luis González Del Valle, Antonio Pérez-Martínez. Treatment of infantile fibrosarcoma associated to an abdominal aortic aneurysm with larotrectinib: a case report. Pediatric hematology and oncology. 2021 Aug;38(5):504-509

Mesh Tags

Substances

PMID: 33622165

search → result