The Role of Granulocyte Transfusions in Optimizing Candidacy for Chimeric Antigen Receptor T-cell Therapy in Patients With Treatment-refractory Infections.

Francesco P Tambaro, Dristhi Ragoonanan, Priti Tewari, Demetrios Petropoulos, Fleur M Aung, Kris M Mahadeo, Sajad Khazal

Journal of pediatric hematology/oncology 2022 Mar 01

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While advancements in cellular therapy have improved outcomes for patients with refractory leukemia, severe infections may hinder access. Granulocyte transfusions, in combination with anti-microbial therapy, may be a safe option to facilitate candidacy for chimeric antigen receptor T-cell therapy in patients with leukemia and prolonged immune-compromised status. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

Citation

Francesco P Tambaro, Dristhi Ragoonanan, Priti Tewari, Demetrios Petropoulos, Fleur M Aung, Kris M Mahadeo, Sajad Khazal. The Role of Granulocyte Transfusions in Optimizing Candidacy for Chimeric Antigen Receptor T-cell Therapy in Patients With Treatment-refractory Infections. Journal of pediatric hematology/oncology. 2022 Mar 01;44(2):e463-e466