Aspirin exacerbated respiratory disease (AERD): molecular and cellular diagnostic & prognostic approaches.

Aspirin-exacerbated respiratory disease (AERD) is characterized by immune cells dysfunction. This study aimed to investigate the molecular mechanisms involved in AERD pathogenesis. Relevant literatures were identified by a PubMed search (2005-2019) of english language papers using the terms "Aspirin-exacerbated respiratory disease", "Allergic inflammation", "molecular mechanism" and "mutation". According to the significant role of inflammation in AERD development, ILC-2 is known as the most important cell in disease progression. ILC-2 produces cytokines that induce allergic reactions and also cause lipid mediators production, which activates mast cells and basophils, ultimately. Finally, Monoclonal antibody and Aspirin desensitization in patients can be a useful treatment strategy for prevention and treatment.

Citation

Habib Hybar, Najmaldin Saki, Mohsen Maleknia, Mana Moghaddasi, Armin Bordbar, Maliheh Naghavi. Aspirin exacerbated respiratory disease (AERD): molecular and cellular diagnostic & prognostic approaches. Molecular biology reports. 2021 Mar;48(3):2703-2711

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PMID: 33625688

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