Activin A backs-up TGF-ß to promote regulatory T cells.

Mara De Martino, Camille Daviaud, Claire Vanpouille-Box

Oncoimmunology 2021 Feb 11

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The mechanisms accountable for the infiltration of regulatory T cells into an irradiated tumor remain elusive. In our recent study, we demonstrate that activin A promotes regulatory T cells in tumors, and impairs anti-tumor immune responses induced by radiotherapy and TGF-β blockade. Dual blockade of activin A and TGF-β may be necessary to reduce regulatory T cells mediated immunosuppression driven by radiation therapy. © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.

Citation

Mara De Martino, Camille Daviaud, Claire Vanpouille-Box. Activin A backs-up TGF-ß to promote regulatory T cells. Oncoimmunology. 2021 Feb 11;10(1):1883288