Correlation Engine 2.0
Clear Search sequence regions


  • algorithms (1)
  • bayesian method (1)
  • drug- target (9)
  • Hep (1)
  • humans (1)
  • PC 3 (1)
  • Sizes of these terms reflect their relevance to your search.

    The prediction of drug-target interaction (DTI) is a key step in drug repositioning. In recent years, many studies have tried to use matrix factorization to predict DTI, but they only use known DTIs and ignore the features of drug and target expression profiles, resulting in limited prediction performance. In this study, we propose a new DTI prediction model named AdvB-DTI. Within this model, the features of drug and target expression profiles are associated with Adversarial Bayesian Personalized Ranking through matrix factorization. Firstly, according to the known drug-target relationships, a set of ternary partial order relationships is generated. Next, these partial order relationships are used to train the latent factor matrix of drugs and targets using the Adversarial Bayesian Personalized Ranking method, and the matrix factorization is improved by the features of drug and target expression profiles. Finally, the scores of drug-target pairs are achieved by the inner product of latent factors, and the DTI prediction is performed based on the score ranking. The proposed model effectively takes advantage of the idea of learning to rank to overcome the problem of data sparsity, and perturbation factors are introduced to make the model more robust. Experimental results show that our model could achieve a better DTI prediction performance. Copyright © 2021 Yihua Ye et al.

    Citation

    Yihua Ye, Yuqi Wen, Zhongnan Zhang, Song He, Xiaochen Bo. Drug-Target Interaction Prediction Based on Adversarial Bayesian Personalized Ranking. BioMed research international. 2021;2021:6690154

    Expand section icon Mesh Tags


    PMID: 33628808

    View Full Text