Xi Xie, Shengsheng Lu, Xiaoyan Pan, Min Zou, Fangfang Li, Haixing Lin, Jianan Hu, Sheng Fan, Jian He
Journal of natural products 2021 Feb 26A new bafilomycin derivative (1) and another seven known bafilomycins (2-8) were isolated from feces-derived Streptomyces sp. HTL16. The structure of 1 was elucidated by 1D and 2D NMR spectroscopic analysis. Biological testing demonstrated that these bafilomycins exhibited potent antiviral activities against the influenza A and SARS-CoV-2 viruses, with IC50 values in the nanomolar range, by inhibiting the activity of endosomal ATP-driven proton pumps.
Xi Xie, Shengsheng Lu, Xiaoyan Pan, Min Zou, Fangfang Li, Haixing Lin, Jianan Hu, Sheng Fan, Jian He. Antiviral Bafilomycins from a Feces-Inhabiting Streptomyces sp. Journal of natural products. 2021 Feb 26;84(2):537-543
PMID: 33631936
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