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    A new bafilomycin derivative (1) and another seven known bafilomycins (2-8) were isolated from feces-derived Streptomyces sp. HTL16. The structure of 1 was elucidated by 1D and 2D NMR spectroscopic analysis. Biological testing demonstrated that these bafilomycins exhibited potent antiviral activities against the influenza A and SARS-CoV-2 viruses, with IC50 values in the nanomolar range, by inhibiting the activity of endosomal ATP-driven proton pumps.


    Xi Xie, Shengsheng Lu, Xiaoyan Pan, Min Zou, Fangfang Li, Haixing Lin, Jianan Hu, Sheng Fan, Jian He. Antiviral Bafilomycins from a Feces-Inhabiting Streptomyces sp. Journal of natural products. 2021 Feb 26;84(2):537-543

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    PMID: 33631936

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