Small molecule inhibitors of cyclin-dependent kinase 9 for cancer therapy.

Aisha Alsfouk

Journal of enzyme inhibition and medicinal chemistry 2021 Dec

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Cyclin-dependent kinase 9 (CDK9) plays a vital role in transcription through regulation of short-lived anti-apoptotic genes required for cancer cell survival. Therefore, targeting CDK9 with small molecule inhibitors has emerged as a potential cancer therapy. This article reviews the most recent CDK9 patent literature (2012-2020) related to small molecule inhibitors in cancer along with their selectivity profile and biological results in preclinical studies.

Citation

Aisha Alsfouk. Small molecule inhibitors of cyclin-dependent kinase 9 for cancer therapy. Journal of enzyme inhibition and medicinal chemistry. 2021 Dec;36(1):693-706