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Directed Evolution of Propionyl-CoA Carboxylase for Succinate Biosynthesis.

Yuwan Liu, Huifeng Jiang

Trends in biotechnology 2021 Apr


filter terms:
  • acetyl coa (1)
  • biosynthesis (1)
  • methylmalonyl coa (2)
  • propionyl- coa (2)
  • succinates (2)
    • Sizes of these terms reflect their relevance to your search.

    Due to low carboxylase activity, CO2 biotransformation is challenging to achieve using natural CO2 fixation pathways. Liu et al. have improved the activity of propionyl-CoA carboxylase (PCC) 94-fold, enabling the efficient synthesis of succinate from acetyl-CoA and paving the way for CO2 assimilation via the 3-hydroxypropionate (3-HP) bicycle or 3-hydroxypropionate/4-hydroxybutyrate (3-HP/4-HB) cycle. Copyright © 2021 Elsevier Ltd. All rights reserved.

    Citation

    Yuwan Liu, Huifeng Jiang. Directed Evolution of Propionyl-CoA Carboxylase for Succinate Biosynthesis. Trends in biotechnology. 2021 Apr;39(4):330-331

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    PMID: 33632542

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