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Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever.

Natalie Lorenz, Timothy K C Ho, Reuben McGregor, Mark R Davies, Deborah A Williamson, Jason K Gurney, Pierre R Smeesters, Michael G Baker, Nicole J Moreland

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2021 Dec 16


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    Rheumatic fever is a serious post-infectious sequela of group A Streptococcus (GAS). Prior GAS exposures were mapped in sera using a large panel of M-type specific peptides. Rheumatic fever patients had serological evidence of significantly more GAS exposures than matched controls suggesting immune priming by repeat infections contributes to pathogenesis. © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

    Citation

    Natalie Lorenz, Timothy K C Ho, Reuben McGregor, Mark R Davies, Deborah A Williamson, Jason K Gurney, Pierre R Smeesters, Michael G Baker, Nicole J Moreland. Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2021 Dec 16;73(12):2322-2325

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    PMID: 33639619

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