SNX25 regulates proinflammatory cytokine expression via the NF-κB signal in macrophages.

Kazuya Nishimura, Tatsuhide Tanaka, Shoko Takemura, Kouko Tatsumi, Akio Wanaka

PloS one 2021

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Innate immunity is the first line of defense against bacterial infection and is initiated by macrophages. Sorting nexin 25 (SNX25) is an SNX family member and is reported to negatively regulate TGF-β signaling by enhancing TGF receptor degradation. However, few studies have focused on the relationship between SNX25 and the immune system. We knocked down SNX25 expression in macrophages and examined inflammatory cytokine expression, a hallmark of innate immunity, after lipopolysaccharide stimulation. SNX25 knockdown increased proinflammatory cytokine expression in RAW 264.7 cells. In addition, SNX25 knockdown activated the NF-κB signal by promoting ubiquitination of IκBα. These results suggest that SNX25 inhibits the NF-κB signal and thereby regulates proinflammatory cytokine expression in macrophages.

Citation

Kazuya Nishimura, Tatsuhide Tanaka, Shoko Takemura, Kouko Tatsumi, Akio Wanaka. SNX25 regulates proinflammatory cytokine expression via the NF-κB signal in macrophages. PloS one. 2021;16(3):e0247840