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Data storage in DNA is a rapidly evolving technology that could be a transformative solution for the rising energy, materials, and space needs of modern information storage. Given that the information medium is DNA itself, its stability under different storage and processing conditions will fundamentally impact and constrain design considerations and data system capabilities. Here we analyze the storage conditions, molecular mechanisms, and stabilization strategies influencing DNA stability and pose specific design configurations and scenarios for future systems that best leverage the considerable advantages of DNA storage.


Karishma Matange, James M Tuck, Albert J Keung. DNA stability: a central design consideration for DNA data storage systems. Nature communications. 2021 Mar 01;12(1):1358

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PMID: 33649304

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