Favre-Racouchot disease (FRD) is an occupational disorder characterized by solar elastosis with open and cystically dilated comedones that tend to appear on the periorbital and temporal face of elderly light-complexioned men. It is a benign condition caused by chronic excessive ultraviolet exposure, as well as ionizing radiation and/or smoking. However, malignant skin neoplasms are uncommonly observed arising in FRD, which suggests a protective role of some element of FRD against carcinogenesis. We explore elastosis as a possibly beneficial tissue response. The clinical manifestations, pathogenesis, and recommended treatment options of this disorder are reviewed. © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.
Christopher Yeh, Robert A Schwartz. Favre-Racouchot disease: protective effect of solar elastosis. Archives of dermatological research. 2022 Apr;314(3):217-222
PMID: 33651174
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