Morpholino-based peptide oligomers: Synthesis and DNA binding properties.

Alessandro Contini, Emanuela Erba, Valeria Bondavalli, Alberto Barbiroli, Maria Luisa Gelmi, Alessandra Romanelli

Biochemical and biophysical research communications 2021 Apr 16

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The chemical structure of oligonucleotide analogues dictates the conformation of oligonucleotide analogue oligomers, their ability to hybridize complementary DNA and RNA, their stability to degradation and their pharmacokinetic properties. In a study aimed at investigating new analogues featuring a neutral backbone, we explored the ability of oligomers containing a morpholino-peptide backbone to bind oligonucleotides. Circular Dichroism studies revealed the ability of our oligomers to interact with DNA, molecular modelling studies revealed the interaction responsible for complex stabilization. Copyright © 2021 Elsevier Inc. All rights reserved.

Citation

Alessandro Contini, Emanuela Erba, Valeria Bondavalli, Alberto Barbiroli, Maria Luisa Gelmi, Alessandra Romanelli. Morpholino-based peptide oligomers: Synthesis and DNA binding properties. Biochemical and biophysical research communications. 2021 Apr 16;549:8-13