Cyclic Anhydrides as Powerful Tools for Bioconjugation and Smart Delivery.

Cyclic anhydrides are potent tools for bioconjugation; therefore, they are broadly used in the functionalization of biomolecules and carriers. The pH-dependent stability and reactivity, as well as the physical properties, can be tuned by the structure of the cyclic anhydride used; thus, their application in smart delivery systems has become very important. This review intends to cover the last updates in the use of cyclic anhydrides as pH-sensitive linkers, their differences in reactivity, and the latest applications found in bioconjugation chemistry or chemical biology, and when possible, in drug delivery.

Citation

Maria Vittoria Spanedda, Line Bourel-Bonnet. Cyclic Anhydrides as Powerful Tools for Bioconjugation and Smart Delivery. Bioconjugate chemistry. 2021 Mar 17;32(3):482-496

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PMID: 33662203

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