A 3-armed multicenter randomized controlled trial: Placental Transfusion in Very Preterm Infants (PT-VPI).

Preterm infants constitute an important proportion of neonatal deaths and various complications, and very preterm infants (VPI) are more likely to develop severe complications, such as intraventricular hemorrhage (IVH), anemia, and sepsis. It has been confirmed that placental transfusion can supplement blood volume in infants and reduce preterm-associated complications, which is further conducive to the development of the nervous system and a better long-term prognosis. Based on these advantages, placental transfusion has been widely used in VPI. There are three main types of placental transfusion: delayed cord clamping (DCC), intact umbilical cord milking (I-UCM), and cut umbilical cord milking (C-UCM). However, the optimal method for PT-VPI remains controversial, and it is urgent to identify the best method of placental transfusion. We plan to fully evaluate the safety and effectiveness of these three placental transfusion methods in VPI in a 3-arm multicenter randomized controlled trial: Placental Transfusion in Very Preterm Infants (PT-VPI). Trial registration: chictr.org.cn, number ChiCTR2000030953. Copyright © 2021 Elsevier Inc. All rights reserved.

Citation

Guang Yue, Yan Wu, Fangping Zhao, Chunyi Zhang, Dan Zhao, Jingjie Lu, Qiaoyan Fang, Xia Li, Yijun Wei, Miao Qian, Lin Yi, Shan Zheng, Ruihua Ba, Liqian Luo, Jiping Luo, Shuai Zhao, Jiangyi Lu, Xia Huang, Guoqing Wei, Yufeng Xi, Shuqiang Gao, Xuhong Hu, Rong Ju. A 3-armed multicenter randomized controlled trial: Placental Transfusion in Very Preterm Infants (PT-VPI). Contemporary clinical trials. 2021 Apr;103:106337

Mesh Tags

PMID: 33662589

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