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Members of the Oxa1 superfamily perform membrane protein insertion in bacteria, the eukaryotic endoplasmic reticulum (ER), and endosymbiotic organelles. Here, we review recent structures of the three ER-resident insertases and discuss the extent to which structure and function are conserved with their bacterial counterpart YidC.

Citation

Melanie A McDowell, Michael Heimes, Irmgard Sinning. Structural and molecular mechanisms for membrane protein biogenesis by the Oxa1 superfamily. Nature structural & molecular biology. 2021 Mar;28(3):234-239

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PMID: 33664512

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