Electrochemical biosensors for measurement of colorectal cancer biomarkers.

Wenxian Zhang, Guangchun Xiao, Jun Chen, Li Wang, Qiongzheng Hu, Jian Wu, Wenhong Zhang, Ming Song, Jinwei Qiao, Chonghai Xu

Analytical and bioanalytical chemistry 2021 Apr

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Colorectal cancer (CRC) is associated with one of the highest rates of mortality among cancers worldwide. The early detection and management of CRC is imperative. Biomarkers play an important role in CRC screening tests, CRC treatment, and prognosis and clinical management; thus rapid and sensitive detection of biomarkers is helpful for early detection of CRC. In recent years, electrochemical biosensors for detecting CRC biomarkers have been widely investigated. In this review, different electrochemical detection methods for CRC biomarkers including immunosensors, aptasensors, and genosensors are summarized. Further, representative examples are provided that demonstrate the advantages of electrochemical sensors modified by various nanomaterials. Finally, the limitations and prospects of biomarkers and electrochemical sensors in detection are also discussed. Graphical abstract.

Citation

Wenxian Zhang, Guangchun Xiao, Jun Chen, Li Wang, Qiongzheng Hu, Jian Wu, Wenhong Zhang, Ming Song, Jinwei Qiao, Chonghai Xu. Electrochemical biosensors for measurement of colorectal cancer biomarkers. Analytical and bioanalytical chemistry. 2021 Apr;413(9):2407-2428