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    Previous work demonstrating the existence of intermediate pluripotency states in post-implantation embryos had ignited a debate on whether "formative" pluripotency can be stabilized in pluripotent stem cell (PSC) lines. In this issue of Cell Stem Cell, two papers show that polarized epithelial and germ cell-competent formative PSCs can be maintained in modified activin-dependent conditions. Copyright © 2021 Elsevier Inc. All rights reserved.


    Ng Shyh-Chang, Lei Li. Stabilizing Formative Pluripotent States with Germ Cell Competency. Cell stem cell. 2021 Mar 04;28(3):361-363

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    PMID: 33667353

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