Antitumor effect of soluble β-glucan as an immune stimulant.

Lijuan Wu, Jun Zhao, Xiaonan Zhang, Shan Liu, Chenyang Zhao

International journal of biological macromolecules 2021 May 15

filter terms:

β-glucans are linear polysaccharides of d-glucose monomers linked through β-glycosidic bonds and are widely present in nature. Different sources lead to their structural differences. β-glucan has long been acknowledged to be a safe and functional component. Its biological activities include lipid-lowering, hypoglycemic, antitumor and immune regulation etc. A large number of studies have shown that soluble β-glucan can bind to their receptors on the surface of immune cells, activates the pro-inflammatory response of innate immune cells, and enhances the host's antitumor defense. A variety of soluble β-glucans have been widely used in clinical antitumor studies as an immunostimulant to treat the cancer patient. In this paper, we reviewed the molecular structure, antitumor immune activities, structure-activity relationship and clinical trials of soluble β-glucans in order to provide the overall scene of β-glucans as immunostimulant to fight the cancer. Copyright © 2021 Elsevier B.V. All rights reserved.

Citation

Lijuan Wu, Jun Zhao, Xiaonan Zhang, Shan Liu, Chenyang Zhao. Antitumor effect of soluble β-glucan as an immune stimulant. International journal of biological macromolecules. 2021 May 15;179:116-124