Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

The mechanistic target of rapamycin (mTOR) and wingless-related integration site (Wnt) signal transduction networks are evolutionarily conserved mammalian growth and cellular development networks. Most cells express many of the proteins in both pathways, and this review will briefly describe only the key proteins and their intra- and extracellular crosstalk. These complex interactions will be discussed in relation to cancer development, drug resistance, and stem cell exhaustion. This review will also highlight the tumor-suppressive tuberous sclerosis complex (TSC) mutated, mTOR-hyperactive lung disease of women, lymphangioleiomyomatosis (LAM). We will summarize recent advances in the targeting of these pathways by monotherapy or combination therapy, as well as future potential treatments.


Jilly Frances Evans, Kseniya Obraztsova, Susan M Lin, Vera P Krymskaya. CrossTORC and WNTegration in Disease: Focus on Lymphangioleiomyomatosis. International journal of molecular sciences. 2021 Feb 24;22(5)

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 33668092

View Full Text