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In the present study, a sunflower-like nanostructure array composed of a series of synaptic nanoparticles and nanospheres was manufactured through an efficient and low-cost colloidal lithography technique. The primary electromagnetic field contribution generated by the synaptic nanoparticles of the surface array structures was also determined by a finite-difference time-domain software to simulate the hotspots. This structure exhibited high repeatability and excellent sensitivity; hence, it was used as a surface-enhanced Raman spectroscopy (SERS) active substrate to achieve a rapid detection of ultra-low concentrations of Alpha-fetoprotein (AFP). This study demonstrates the design of a plasmonic structure with strong electromagnetic coupling, which can be used for the rapid detection of AFP concentration in clinical medicine.


Xiaoyu Zhao, Aonan Zhu, Yaxin Wang, Yongjun Zhang, Xiaolong Zhang. Sunflower-Like Nanostructure with Built-In Hotspots for Alpha-Fetoprotein Detection. Molecules (Basel, Switzerland). 2021 Feb 23;26(4)

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PMID: 33672380

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