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Peripheral nerve injury frequently evokes chronic neuropathic pain. This is initiated by a transient inflammatory response that leads to persistent excitation of dorsal root ganglion (DRG) neurons by inflammatory cytokines such as interleukin 1β(IL-1β). In non-neuronal cells such as lymphocytes, interleukin 1 exerts actions at attomolar (aM; 10-18 M) concentrations. We now report that DRG neurons in defined-medium, neuron-enriched culture display increased excitability following 5-6 d exposure of 1aM IL-1β. This response is mediated in part by type 1 interleukin receptors and involves decreased function of putative KCa1.1 channels. This finding provides new insights into the neuroimmune interactions responsible for neuropathic pain. Copyright © 2021 Elsevier B.V. All rights reserved.


Patrick L Stemkowski, Nataliya Bukhanova-Schulz, Troy Baldwin, Elena Posse de Chaves, Peter A Smith. Are sensory neurons exquisitely sensitive to interleukin 1β? Journal of neuroimmunology. 2021 May 15;354:577529

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PMID: 33676084

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