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    Transient receptor potential (TRP) ion channels are a super-family of ion channels that mediate transmembrane cation flux with polymodal activation, ranging from chemical to physical stimuli. Furthermore, due to their ubiquitous expression and role in human diseases, they serve as potential pharmacological targets. Advances in cryo-EM TRP channel structural biology has revealed general, as well as diverse, architectural elements and regulatory sites among TRP channel subfamilies. Here, we review the endogenous and pharmacological ligand-binding sites of TRP channels and their regulatory mechanisms. Copyright © 2021 Elsevier Ltd. All rights reserved.

    Citation

    Yaxian Zhao, Bridget M McVeigh, Vera Y Moiseenkova-Bell. Structural Pharmacology of TRP Channels. Journal of molecular biology. 2021 Mar 05:166914


    PMID: 33676926

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