Dual role of interleukin-33 in tumors.

Qianqian Liu, Di Lu, Jiahua Hu, Junchao Liang, Huoying Chen

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 2021 Feb 28

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Interleukin-33 (IL-33) is a new member of the IL-1 cytokine family which plays roles in the nucleus as a nuclear factor and is released by damaged or necrotic cells to act as a cytokine. It can be released via damaged or necrotic cells and functions as a cytokine. The released IL-33 activates the downstream NF-κB and MAPKs signaling pathways through the isomers of the specific receptor ST2 and the interleukin-1 receptor accessory protein (IL-1RAcP), resulting in danger signals and the activated multiple immune responses. IL-33 is abnormally expressed in various tumors and involves in tumorigenesis, development, and metastasis. Moreover, IL-33 can play both pro-tumor and anti-tumor roles in the same type of tumor.

Citation

Qianqian Liu, Di Lu, Jiahua Hu, Junchao Liang, Huoying Chen. Dual role of interleukin-33 in tumors. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 2021 Feb 28;46(2):169-175