The Roles of Envelope Glycoprotein M in the Life Cycle of Some Alphaherpesviruses.

The envelope glycoprotein M (gM), a surface virion component conserved among alphaherpesviruses, is a multiple-transmembrane domain-containing glycoprotein with a complex N-linked oligosaccharide. The gM mediates a diverse range of functions during the viral life cycle. In this review, we summarize the biological features of gM, including its characterization and function in some specicial alphaherpesviruses. gM modulates the virus-induced membrane fusion during virus invasion, transports other proteins to the appropriate intracellular membranes for primary and secondary envelopment during virion assembly, and promotes egress of the virus. The gM can interact with various viral and cellular components, and the focus of recent research has also been on interactions related to gM. And we will discuss how gM participates in the life cycle of alphaherpesviruses. Copyright © 2021 Li, Wang, Cheng, Jia, Yang, Wu, Zhu, Zhao, Chen, Liu, Zhang, Ou, Mao, Gao, Sun, Wen and Tian.

Citation

Chunmei Li, Mingshu Wang, Anchun Cheng, Renyong Jia, Qiao Yang, Ying Wu, Dekang Zhu, Xinxin Zhao, Shun Chen, Mafeng Liu, Shaqiu Zhang, Xumin Ou, Sai Mao, Qun Gao, Di Sun, Xingjian Wen, Bin Tian. The Roles of Envelope Glycoprotein M in the Life Cycle of Some Alphaherpesviruses. Frontiers in microbiology. 2021;12:631523

PMID: 33679658

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