The Role of Posttranslational Modification and Mitochondrial Quality Control in Cardiovascular Diseases.

Jinlin Liu, Li Zhong, Rui Guo

Oxidative medicine and cellular longevity 2021

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Cardiovascular disease (CVD) is the leading cause of death in the world. The mechanism behind CVDs has been studied for decades; however, the pathogenesis is still controversial. Mitochondrial homeostasis plays an essential role in maintaining the normal function of the cardiovascular system. The alterations of any protein function in mitochondria may induce abnormal mitochondrial quality control and unexpected mitochondrial dysfunction, leading to CVDs. Posttranslational modifications (PTMs) affect protein function by reversibly changing their conformation. This review summarizes how common and novel PTMs influence the development of CVDs by regulating mitochondrial quality control. It provides not only ideas for future research on the mechanism of some types of CVDs but also ideas for CVD treatments with therapeutic potential. Copyright © 2021 Jinlin Liu et al.

Citation

Jinlin Liu, Li Zhong, Rui Guo. The Role of Posttranslational Modification and Mitochondrial Quality Control in Cardiovascular Diseases. Oxidative medicine and cellular longevity. 2021;2021:6635836