Guilherme S Caleffi, Juliana de O C Brum, Angela T Costa, Jorge L O Domingos, Paulo R R Costa
The Journal of organic chemistry 2021 Mar 193-Arylidenechroman-4-ones and 2-arylidene-1-tetralones are hydrogenated to cis-benzylic alcohols in dr's and er's up to 99:1 via a C═C and C═O one-pot reduction in the presence of 2-5 mol % Noyori-Ikariya-type RuII chiral complexes and HCO2Na as a hydrogen source under asymmetric transfer hydrogenation-dynamic kinetic resolution (ATH-DKR) conditions. The oxidation of theses substrates resulted in the enantioselective synthesis of the natural homoisoflavanone dihydrobonducellin and its carba-analogues.
Guilherme S Caleffi, Juliana de O C Brum, Angela T Costa, Jorge L O Domingos, Paulo R R Costa. Asymmetric Transfer Hydrogenation of Arylidene-Substituted Chromanones and Tetralones Catalyzed by Noyori-Ikariya Ru(II) Complexes: One-Pot Reduction of C═C and C═O bonds. The Journal of organic chemistry. 2021 Mar 19;86(6):4849-4858
PMID: 33683900
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