Hsin-Kai Tseng, Yung-Yu Su, Ting-Wei Chang, Hsin-Chien Liu, Pei-Jhen Li, Pei-Yun Chiang, Chun-Cheng Lin
Chemical communications (Cambridge, England) 2021 Apr 11Herein, we applied PmST1 (a sialyltransferase) to achieve acceptor-mediated regioselective sialylation (AMRS) on the nonreducing end GalNH2 or GalAz (2-azido-2-deoxy galactose). Thus, C5 and C8-modified sialic acid was efficiently assembled on GalNH2 (or GalAz) to achieve the synthesis of the GAA-7 (one of the echinodermatous gangliosides with higher neuritogenic activity) glycan moiety.
Hsin-Kai Tseng, Yung-Yu Su, Ting-Wei Chang, Hsin-Chien Liu, Pei-Jhen Li, Pei-Yun Chiang, Chun-Cheng Lin. Acceptor-mediated regioselective enzyme catalyzed sialylation: chemoenzymatic synthesis of GAA-7 ganglioside glycan. Chemical communications (Cambridge, England). 2021 Apr 11;57(28):3468-3471
PMID: 33688902
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